![]() ![]() 28 in the Journal of Experimental Medicine, describes a previously unknown way a virus can trigger autoimmunity. Months after infection, the mice develop an autoimmune disease of the stomach driven by self-destructive T cells. In the study, which was conducted in mice, the researchers showed that murine roseolovirus infects the thymus - the organ where self-destructive T cells are identified and eliminated - and disrupts the screening process in the organ. The researchers investigated the impact of viral infection on T cells, a group of immune cells that play a key role in many autoimmune conditions. Louis have discovered that a viral infection can set a destructive process in motion, culminating in autoimmunity long after the infection has resolved. Researchers at Washington University School of Medicine in St. Scientists have made progress in identifying genetic factors that put people at risk, but the environmental triggers have proven more elusive. Louis have discovered that roseolovirus can trigger autoimmunity in a previously unknown way: by disrupting the process by which immune cells learn to avoid targeting their own body's cells and tissues.Īutoimmune diseases such as rheumatoid arthritis and Type 1 diabetes are thought to arise when people with a genetic susceptibility to autoimmunity encounter something in the environment that triggers their immune systems to attack their own bodies. Studying mice, researchers at Washington University School of Medicine in St. Roseolovirus particles emerge from an infected immune cell (above). ![]() In mice, roseolovirus disrupts immune cells’ process of learning self-recognitionīy Tamara Bhandari News Release New way viruses trigger autoimmunity discovered ![]()
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